Milestones in the Buck/Shepherd/Goddard collaboration
To understand the binding characteristics of odorants to the odor receptors at the atomic level.
- Obtained sequence data (Malnic & Buck)
- derived atomic level structure (Singer , Shepherd, Floriano, Nagarajan & Goddard)
- identified the binding site of simple organic alcohols and acids(Floriano, Nagarajan & Goddard)
- a protocol for deriving structures & automation of these procedures for throughput(Floriano, Nagarajan & Goddard)