Effect of Gln Substitution
- We observed in some trajectories that helix propagation has been blocked for a periods of time because of the HBs formed between Gln sidechain and the backbone of the peptide. Gln sidechain is also a steric hindrance for helix propagation.
- Gln sidechain form 2 HBs with adjacent residues.
- Gln sidechain steps out and the 2 atoms previous bound with Gln sidechain form i, i+3 HBs.
- i,i+3 => i,i+4 HBs.