Key Olfaction Facts
- 1.- One receptor recognizes multiple odorants
- S19: CnCOOH (n=6-9), CnCOH (n=7-9)
- 2.- One odorant recognized by multiple ORs
- Nonanoic acid: 22 out of 47
- 3.-Similar structures different odors
- Hexanol : sweet, herbal, woody
- Hexanoic : rancid, sweaty, sour
- Full Structural Recognition versus Mean Field
- 1 & 2 imply mean field recognition
- 3 implies full structural recogntion
B. Malnic, J. Hirono, T. Sato, L.B. Buck; Combinatorial Receptor Codes for Odors, Cell, Vol 96, 713-723, March 5, 1999